Daratumumab, Azacitidine, and Dexamethasone for Treatment of Patients With Recurrent or Refractory Multiple Myeloma Previously Treated With Daratumumab
Summary
Third Opinion Trial Synopsis:
This study is testing if using three drugs - daratumumab, azacitidine, and dexamethasone - can help treat patients with multiple myeloma that has come back or has not responded to previous treatment. Daratumumab is a type of medicine that attaches to a protein found on myeloma cells and prevents their growth. Azacitidine is a chemotherapy drug that stops the growth of cancer cells in different ways. Dexamethasone is a steroid that helps decrease inflammation and lower the body's immune response. Using azacitidine may make daratumumab work better to destroy the cancer cells.
This study is testing if using three drugs - daratumumab, azacitidine, and dexamethasone - can help treat patients with multiple myeloma that has come back or has not responded to previous treatment. Daratumumab is a type of medicine that attaches to a protein found on myeloma cells and prevents their growth. Azacitidine is a chemotherapy drug that stops the growth of cancer cells in different ways. Dexamethasone is a steroid that helps decrease inflammation and lower the body's immune response. Using azacitidine may make daratumumab work better to destroy the cancer cells.
*Third Opinion AI Generated Synopsis
Trial Summary
This phase II trial studies how well daratumumab, azacitidine, and dexamethasone work in treating patients with multiple myeloma that has come back (recurrent) or has not responded to treatment (refractory) and was previously treated with daratumumab. Daratumumab is an antibody made up of immune cells that attaches to a protein on myeloma cells, called cluster of differentiation 38 (CD38). CD38 is found in higher levels on tumor cells than on normal cells. Daratumumab prevents the growth of tumors who have high levels of CD38 by causing those cells to die. Chemotherapy drugs, such as azacitidine, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Dexamethasone is a steroid that helps decrease inflammation and lowers the body's normal immune response to help reduce the effect of any infusion-related reactions. Giving azacitidine may help increase the levels of CD38 on the tumor cells to increase the function of daratumumab to attach to those tumor cells to help destroy them.
This phase II trial studies how well daratumumab, azacitidine, and dexamethasone work in treating patients with multiple myeloma that has come back (recurrent) or has not responded to treatment (refractory) and was previously treated with daratumumab. Daratumumab is an antibody made up of immune cells that attaches to a protein on myeloma cells, called cluster of differentiation 38 (CD38). CD38 is found in higher levels on tumor cells than on normal cells. Daratumumab prevents the growth of tumors who have high levels of CD38 by causing those cells to die. Chemotherapy drugs, such as azacitidine, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Dexamethasone is a steroid that helps decrease inflammation and lowers the body's normal immune response to help reduce the effect of any infusion-related reactions. Giving azacitidine may help increase the levels of CD38 on the tumor cells to increase the function of daratumumab to attach to those tumor cells to help destroy them.
Locations & Contact
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