Leflunomide, Pomalidomide, and Dexamethasone for the Treatment of Relapsed or Refractory Multiple Myeloma
Summary
Third Opinion Trial Synopsis:
This study is looking at how well three different drugs, leflunomide, pomalidomide, and dexamethasone, work together to treat multiple myeloma, a type of cancer that has come back or doesn't respond to treatment. These drugs work in different ways to stop cancer cells from growing and spreading. The study is trying to see if using all three drugs together is better than using just two of them.
This study is looking at how well three different drugs, leflunomide, pomalidomide, and dexamethasone, work together to treat multiple myeloma, a type of cancer that has come back or doesn't respond to treatment. These drugs work in different ways to stop cancer cells from growing and spreading. The study is trying to see if using all three drugs together is better than using just two of them.
*Third Opinion AI Generated Synopsis
Trial Summary
This phase II trial studies how well leflunomide, pomalidomide, and dexamethasone work for the treatment of multiple myeloma that has come back (relapsed) or does not respond to treatment (refractory). Leflunomide may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Immunotherapy with pomalidomide, may induce changes in body's immune system and may interfere with the ability of tumor cells to grow and spread. Chemotherapy drugs, such as dexamethasone, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving leflunomide with pomalidomide and dexamethasone may work better in treating multiple myeloma compared to pomalidomide and dexamethasone alone.
This phase II trial studies how well leflunomide, pomalidomide, and dexamethasone work for the treatment of multiple myeloma that has come back (relapsed) or does not respond to treatment (refractory). Leflunomide may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Immunotherapy with pomalidomide, may induce changes in body's immune system and may interfere with the ability of tumor cells to grow and spread. Chemotherapy drugs, such as dexamethasone, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving leflunomide with pomalidomide and dexamethasone may work better in treating multiple myeloma compared to pomalidomide and dexamethasone alone.
Locations & Contact
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