A Study to Learn About the Study Medicine (Elranatamab) Either Alone or in Combination With Dexamethasone in Participants With Multiple Myeloma That Has Come Back After Responding to Treatment or Has Not Responded to Treatment
Summary
Third Opinion Trial Synopsis:
This study is being done to see if a new medicine called elranatamab is safe and effective for people with a type of cancer called multiple myeloma that has come back after treatment or hasn't responded to treatment. They will give the medicine in different doses over time to see if it's safe and how well it works. The people in the study will get the medicine by injection at a clinic and will need to go to the clinic less often as time goes on. They will be in the study for at least two years.
This study is being done to see if a new medicine called elranatamab is safe and effective for people with a type of cancer called multiple myeloma that has come back after treatment or hasn't responded to treatment. They will give the medicine in different doses over time to see if it's safe and how well it works. The people in the study will get the medicine by injection at a clinic and will need to go to the clinic less often as time goes on. They will be in the study for at least two years.
*Third Opinion AI Generated Synopsis
Trial Summary
The purpose of Part 1 and Part 2 is to evaluate the safety of a step-up dosing approach (starting with low doses followed by higher doses) of the study medicine (elranatamab) in participants with multiple myeloma that has come back after responding to treatment or has not responded to treatment (relapsed/refractory multiple myeloma). The purpose of Part 3 of the study is to evaluate the safety and efficacy of elranatamab in combination with dexamethasone during the first 6 cycles followed by elranatamab monotherapy. This study will also look at the safety and efficacy of different doses of elranatamab, as well as different intervals between doses. Participants in the study will receive elranatamab as an injection under the skin at the study clinic. After the initial step-up doses, participants will start receiving one dose every week. The frequency of clinic visits for injections may then decrease over time. Participation will be at least two years.
The purpose of Part 1 and Part 2 is to evaluate the safety of a step-up dosing approach (starting with low doses followed by higher doses) of the study medicine (elranatamab) in participants with multiple myeloma that has come back after responding to treatment or has not responded to treatment (relapsed/refractory multiple myeloma). The purpose of Part 3 of the study is to evaluate the safety and efficacy of elranatamab in combination with dexamethasone during the first 6 cycles followed by elranatamab monotherapy. This study will also look at the safety and efficacy of different doses of elranatamab, as well as different intervals between doses. Participants in the study will receive elranatamab as an injection under the skin at the study clinic. After the initial step-up doses, participants will start receiving one dose every week. The frequency of clinic visits for injections may then decrease over time. Participation will be at least two years.
Locations & Contact
Fill out the form and "Notify Multiple Myeloma Research Foundation" to let the Multiple Myeloma Research Foundation know you are interested in this trial.
Contacts: