Radioimmunotherapy (111Indium/225Actinium-DOTA-daratumumab) for the Treatment of Relapsed/Refractory Multiple Myeloma
Summary
Third Opinion Trial Synopsis:
This is a trial to test a new treatment for people who have a type of cancer called multiple myeloma that doesn't respond to normal treatment or has come back. The treatment involves three things: a drug called daratumumab, and two other drugs called 111In-DOTA-daratumumab and 225Ac-DOTA-daratumumab. These last two drugs are special because they have a tiny bit of radiation in them that can target the cancer cells more effectively. The doctors want to see if using these three drugs together can kill more cancer cells.
This is a trial to test a new treatment for people who have a type of cancer called multiple myeloma that doesn't respond to normal treatment or has come back. The treatment involves three things: a drug called daratumumab, and two other drugs called 111In-DOTA-daratumumab and 225Ac-DOTA-daratumumab. These last two drugs are special because they have a tiny bit of radiation in them that can target the cancer cells more effectively. The doctors want to see if using these three drugs together can kill more cancer cells.
*Third Opinion AI Generated Synopsis
Trial Summary
This phase I trial tests the safety, side effects, and best dose of actinium Ac 225-DOTA-daratumumab (225Ac-DOTA-daratumumab) in combination with daratumumab and indium In 111-DOTA-daratumumab (111In-DOTA-daratumumab) in treating patients with multiple myeloma that does not respond to treatment (refractory) or that has come back (recurrent). Daratumumab is a monoclonal antibody that may interfere with the ability of cancer cells to grow and spread. 111In-DOTA-daratumumab and 225Ac-DOTA-daratumumab are forms of radioimmunotherapy in which a monoclonal antibody, daratumumab, has been linked to a radiotracer to allow for targeted delivery of the treatment to cancer cells. Giving all three together may kill more cancer cells.
This phase I trial tests the safety, side effects, and best dose of actinium Ac 225-DOTA-daratumumab (225Ac-DOTA-daratumumab) in combination with daratumumab and indium In 111-DOTA-daratumumab (111In-DOTA-daratumumab) in treating patients with multiple myeloma that does not respond to treatment (refractory) or that has come back (recurrent). Daratumumab is a monoclonal antibody that may interfere with the ability of cancer cells to grow and spread. 111In-DOTA-daratumumab and 225Ac-DOTA-daratumumab are forms of radioimmunotherapy in which a monoclonal antibody, daratumumab, has been linked to a radiotracer to allow for targeted delivery of the treatment to cancer cells. Giving all three together may kill more cancer cells.
Locations & Contact
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