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Comparing Combinations of Drugs to Treat Newly Diagnosed Multiple Myeloma (NDMM) When a Stem Cell Transplant is Not a Medically Suitable Treatment

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Third Opinion Trial Synopsis:
Scientists are studying ways to treat a cancer called multiple myeloma in people who are too old or not healthy enough to get a stem cell transplant. They are trying different combinations of four drugs: bortezomib, lenalidomide, dexamethasone, and daratumumab. These drugs may help stop cancer cells from growing or kill them. Some patients will get one combination of drugs, others will get a different one, and the scientists will see which one works best to control and shrink the cancer. This study includes two parts of treatment: the first one is called "induction" and is the first treatment that a patient gets for cancer. The second one is called "maintenance" and is given after the first treatment to help keep the cancer from coming back.
*Third Opinion AI Generated Synopsis

Trial Summary
This phase III trial compares three-drug induction regimens followed by double-or single-drug maintenance therapy for the treatment of newly diagnosed multiple myeloma in patients who are not receiving a stem cell transplant and are considered frail or intermediate-fit based on age, comorbidities, and functional status. Treatment for multiple myeloma includes initial treatment (induction) which is the first treatment a patient receives for cancer followed by ongoing treatment (maintenance) which is given after initial treatment to help keep the cancer from coming back. There are three combinations of four different drugs being studied. Bortezomib is one of the drugs that may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Lenalidomide works by helping bone marrow to produce normal blood cells and killing cancer cells. Anti-inflammatory drugs, such as dexamethasone, lower the body's immune response and are used with other drugs in the treatment of some types of cancer. Daratumumab and hyaluronidase-fihj is a monoclonal antibody that may interfere with the ability of cancer cells to grow and spread. Patients receive 1 of 3 combinations of these drugs for treatment to determine which combination of study drugs works better to shrink and control multiple myeloma.

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