Map of Third Opinion's partner sites across the US

Maximize & Accelerate Clinical Trial Enrollment

A clinical research technology partner of sponsors and sites, Third Opinion AI-enables and analyzes site EHR data to maximize patient enrollment. Third Opinion processes unstructured notes, documents, and media files the EHR can't query — surfacing every trial-eligible patient alongside the site, with physician oversight at every step.

Urology & Oncology Technology Partner

18

Uro-Oncology Sites in Network

~8M

Patients Covered

9

Sponsor Trials Run

4

Disease States Covered — NMIBC · mCRPC · UTUC · UTI

How Third Opinion Works

Across the clinical trial industry, patient enrollment is the bottleneck:

  • 50%of trial sites enroll zero or one patient in their studies
  • 80%of trials miss their initial enrollment timeline

Third Opinion exists to change those numbers — without adding work for your staff.

Find Eligible Patients Who'd Be Missed

Surfacing trial-ready candidates hidden in unstructured EHR notes, documents, and media that structured queries can't reach.

Find Patients Faster

Matching patients against inclusion and exclusion criteria in days, not months — compressing your path to full enrollment.

Turn Unstructured Data Into Action

AI-enabled chart review with physician oversight at every step — and zero workflow change for your clinical staff.

How It Works: From 600,000 Charts To 6 Eligible Patients

An NMIBC trial example: how Third Opinion narrows a typical large urology practice's population to a short list of candidates worth a site's time.

STARTING POPULATION

600,000

Total patients at a typical large urology group practice

▼ 0.5% · STRUCTURED EHR FILTER

3,000

NMIBC-potential patients identified in the last 12 months

▼ 2.3% · UNSTRUCTURED DATA AI

70

Pathology-confirmed CIS cases in the last 90 days

▼ 8.6% · FULL CRITERIA MATCH

6

Patients meet all criteria and go to the site for review

Figures are illustrative and reflect a representative site; individual practice results will vary.

Built For Sponsors. Built For Sites.

One platform, two partners — each motivated to rapidly identify trial-eligible patients.

For Sponsors

Accelerate your uro-oncology trial with a network of 18+ activation-ready urology sites covering ~8M patients. Identify eligible patients your EHR can't surface, and shorten your path to full enrollment.

For Research Sites

Grow clinical research revenue without changing your workflow. Third Opinion AI-enables your EHR, surfaces trial-ready patients, and helps you onboard more sponsor trials.

Proven At The Site Level

Built By Leaders From

  • Astellas
  • Johnson & Johnson
  • Veradigm
  • Allscripts
  • Epic
  • Founded by physicians, led by veterans of Astellas, Veradigm, and Practice Fusion
  • AI-powered patient identification, physician-reviewed at every step
  • No workflow change required at the site level
  • HIPAA-compliant EHR integration — Epic, Athena, Veradigm, and more

Let us accelerate recruitment while you drive your research forward